独立行政法人 国立病院機構 東京医療センター臨床研究センター 感覚器センター

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研究部

分子細胞生物学研究部

 

分子細胞生物学研究部 

部長 岩田 岳

視覚生物学研究室 | 神経生物学研究室

研究部の紹介

 

1)はじめに

ヒトは外部情報の80%を視覚に依存しており、急速な高齢化と視覚を酷使する生活環境によって視覚障害者は増加すると予測されます。分子細胞生物学研究部では基礎研究者と臨床医が協力して、網膜疾患(加齢黄斑変性、正常眼圧緑内障、遺伝性網脈絡膜疾患)の中でも遺伝因子との関連が強い疾患を対象に病因・病態機序の解明と診断・治療を目的とした臨床研究を行っています。

 

2)研究対象の網膜疾患

加齢黄斑変性

黄斑は角膜と水晶体によって収束した光が網膜上で結像する領域で、視細胞が集中する視力を決定する重要な部位です。ここが障害されると著しい視力低下に至ります。黄斑が障害される代表的な眼疾患として加齢黄斑変性がありますが、米国では失明率も最も高い難治性眼疾患であり、日本でも急速な高齢化によって患者数は増加しています。黄斑は高い解像度の視力を獲得した霊長類などの動物で観察される網膜構造であり、通常の実験に使用される夜行性のゲツ歯類(マウス、ラット等)には存在しません。我々は優性遺伝子によって生後2年で黄斑部にドルーゼンが観察される世界的にもめずらしいカニクイザルについて発症機序の研究や薬効評価を行っています。また、日本人の加齢黄斑変性、ポリープ状脈絡膜血管症の患者を対象とした全ゲノム相関解析(GWAS)から染色体10番の領域に強く相関することを発見し、感受性遺伝子HTRA1の転写活性が増加とその分子メカニズムを明らかにしました。遺伝子改変マウスにおいてHTRA1の転写活性を上げたところ、脈絡膜血管新生が生後1年で約2割のマウスで確認されました。HTRA1遺伝子は感受性遺伝子の中でも最も加齢黄斑変性と相関し、オッズ比が高い領域に存在します。

 

家族性の緑内障と家族性の視神経萎縮症

緑内障は網膜神経節細胞の委縮によって発症する、患者数の最も多い眼疾患です。遺伝因子あるいは多因子(遺伝子、環境、習慣)が原因と考えられており、加齢にともなって有病率が上昇します。我々は家族性の開放隅角緑内障、偽落屑緑内障、視神経症の原因遺伝子を探索しています。緑内障や視神経症の原因遺伝子を明らかにし、遺伝子改変マウス(オプチニュリン)を作製し、その発症メカニズムの解明や治療薬の探索を行っています。特に正常眼圧緑内障の原因遺伝子オプチニュリン(OPTN)のE50Kノックインマウスは患者に類似した病態を再現し、この疾患モデルの病態を抑制する薬を発見しました。

 

遺伝性網脈絡膜疾患(36疾患) 

Japan Eye Genetics Consortium (JEGC)

日本医療研究開発機構 (Japan Agency for Medical Research and Development, AMED)の委託研究事業の拠点班として、遺伝性網脈絡膜疾患群を専門とする国内30の大学病院、眼科施設と連携し、次世代シークエンサーを用いた大規模な全エクソーム解析を行っています。これまでの結果から日本人の8割の患者家族は欧米人とは異なる遺伝子変異によって発症していることが明らかになりました。日本人の原因遺伝子と病態との関係を完全に明らかにするために遺伝子解析を継続し、情報を収集する計画です。患者の多くが新規遺伝子変異であることから、自然歴の情報を収集し、データベース化し、遺伝子治療や薬による臨床試験、治験、治療法開発に役立てています。すでにRP1L1、C21orf2、CCT2、LRRTM4などの新規遺伝子を発見しました。解明された多数の新規原因遺伝子については、その病態機序を解明するために、変異体タンパク質の機能解析やノックインマウス、ノックアウトマウスの病理学的解析を行っています。

 

3)研究内容

症例情報・患者検体の収集とデータベースの構築

AMED委託研究事業、国立病院機構ネットワーク研究事業として、大学病院や国立病院機構病院と連携して症例情報と患者検体(唾液、血液)を収集しています。症例情報は各眼科施設からオンライン症例情報収集システムに登録され、ゲノム情報を付加したGenotype-PhenotypeデータベースをAMEDの主導で構築しています。

 

ゲノム解析

患者検体(血液・唾液)からDNAを抽出し、次世代DNAシークエンス(全エクソーム解析、全ゲノム解析)によって、原因遺伝子変異の探索を行っています。JEGC研究班では家族、親族全員の遺伝子解析を主体としており、より信頼性の高い遺伝子解析をめざしています。遺伝子情報は臨床情報とリンクされてデータベース化されています。

 

変異体タンパク質の機能解析

新規遺伝子変異のタンパク質への影響を調べるために、変異体の活性、タンパク質間相互作用、変異体の細胞内での状態を調べています。

 

患者iPS細胞の作製

我々が発見した新規遺伝子によって発症する患者iPS細胞を樹立し、網膜を構成する細胞へと分化誘導することによって、患者の網膜を再現し、細胞レベルでの病因解明に向けた研究も進められています。

 

疾患動物モデルの作製

全エクソーム解析、全ゲノム解析によって明らかにされた新規遺伝子については、遺伝子改変技術CRISPR/Cas9を用いてマウスモデル(ノックインマウス、ノックアウトマウス)を作製し、患者と同じ病態を動物で再現し、その詳細な病理学的観察によって発症機序の解明をめざしています。また、加齢黄斑変性の初期病態に類似する自然発症のカニクイザルについて病理学的あるいは遺伝学的解析が行われています。

 

4)国際協力

Global Eye Genetics Consortium (GEGC) の設立

日本人の原因遺伝子変異は大陸を起源としているものが多数含まれている可能性があります。2014年に我々は世界各国の眼科施設と連携して、世界眼遺伝学コンソーシアム (Global Eye Genetics Consortium, GEGC)を設立しました。現在ではアメリカ、イギリス、フランス、ブラジル、インド、中国、韓国、ASEAN諸国、スリランカ、バングラデッシュ、UAE,トルコ、イランを含む、世界の国々と情報交換を行い、データベースを構築し、共同研究による遺伝子解析が進行中です。写真(GEGC全体会議、ARVO 2016年5月、シアトル)

 

 

XXII International Society for Eye Research (ISER、第22回国際眼研究学会)の開催

ISERが20年ぶりに日本で開催されました。日本での開催は4回目となります。ISERは1968年にオックスフォード大学で開催されてから、2年おきにヨーロッパ、アメリカ大陸、アジアの順番で異なる都市で開催されてきました。招待発表を主体としており、ポスター発表を含めた約1,000人規模の学会です。本学会では緑内障、水晶体と白内障、角膜と眼表面、眼のイメージング、眼の免疫、網膜色素上皮と脈絡膜、網膜の細胞生物学、眼薬理学と治療法、網膜の発生、眼の遺伝学の分野についてISERとしては最大の135セッションが開かれました。39か国から1,020人が参加し、約85%の参加者が外国人、日本人の参加者も例年の3倍以上でした。近年のISERとしては最も高い評価をいただきました。ISER 2018はアイルランドで開催される予定です。 

 

学会レセプション (2016年9月25〜29日、新宿、京王プラザホテル, http://iserbiennialmeeting2016.org/)

 

5)研究部メンバー

  
部長

岩田 岳

秘書

照山 遊

主任研究員

須賀 晶子

研究員

Rossmiller, Brian

研究員

潘 洋 (Pan, Yang)

研究員

Bagheri, Mozhdeh

研究補助員

峰松 尚子

派遣社員

山本 めぐみ (JAC)

客員研究員

吉武 和敏 (東京大学農学部)

客員研究員

伊藤 拓己 (東京大学農学部)

客員研究員

地頭所 光 (東京大学農学部)

客員研究員

Sankaranarayanan, Rajkumar (Aditya Jyot Foundation for Twinkling Little Eyes)

客員研究員

峯岸 ゆり子(有明がん研究所)

客員研究員

中山 真央

客員研究員

Shiqin, Yuan (Ningxia Eye Hospital)

客員研究員

Li, Huiping (Ningxia Eye Hospital)

客員研究員

Yang, Liu (Ningxia Eye Hospital)

客員研究員

Sultan, William (CE Schimit College of Med)

客員研究員

木村 至 (東海大学八王子病院)

 

連絡先

〒152-8902 東京都目黒区東が丘2−5−1
独立行政法人 国立病院機構 東京医療センター
臨床研究センター (感覚器センター)
分子細胞生物学研究部
岩田 岳
takeshi.iwata at kankakuki.go.jp

 

論文・出版

 

Kameya S, Fujinami K, Ueno S, Hayashi T, Kuniyoshi K, Ideta R, Kikuchi S, Kubota D, Yoshitake K, Katagiri S, Sakuramoto H, Kominami T, Terasaki H, Yang L, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Miyake Y, Iwata T, Tsunoda K; Japan Eye Genetics Consortium. Phenotypical Characteristics of POC1B-Associated Retinopathy in Japanese Cohort: Cone Dystrophy With Normal Funduscopic Appearance. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3432-3446. doi: 10.1167/iovs.19-26650. PubMed PMID: 31390656.

 

Tsunoda K, Fujinami K, Yoshitake K, Iwata T. Late-onset night blindness with peripheral flecks accompanied by progressive trickle-like macular degeneration. Doc Ophthalmol. 2019 Jul 8. doi: 10.1007/s10633-019-09705-7. [Epub ahead of print] PubMed PMID: 31286363.

 

Fujinami-Yokokawa Y, Pontikos N, Yang L, Tsunoda K, Yoshitake K, Iwata T, Miyata H, Fujinami K, Japan Eye Genetics Consortium OBO. Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-Domain Optical Coherence Tomography Utilizing Deep Learning Techniques. J Ophthalmol. 2019 Apr 9;2019:1691064. doi: 10.1155/2019/1691064. eCollection 2019. PubMed PMID: 31093368; PubMed Central PMCID: PMC6481010.

 

Fujinami K, Yang L, Joo K, Tsunoda K, Kameya S, Hanazono G, Fujinami-Yokokawa Y, Arno G, Kondo M, Nakamura N, Kurihara T, Tsubota K, Zou X, Li H, Park KH, Iwata T, Miyake Y, Woo SJ, Sui R; East Asia Inherited Retinal Disease Society study group. Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake Disease): East Asia Occult Macular Dystrophy Studies Report Number 1. Ophthalmology. 2019 Apr 25. pii: S0161-6420(19)30138-1. doi: 10.1016/j.ophtha.2019.04.032. [Epub ahead of print] PubMed PMID: 31028767.

 

Gan YJ, Fang AW, Liu C, Liu BJ, Yang FM, Guan JT, Lan CL, Dai XD, Li T, Cao Y, Ran Y, Gong XH, Jin ZB, Cui RZ, Iwata T, Qu J, Lu F, Chi ZL. Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration. Front Neurosci. 2019 Apr 3;13:326. doi: 10.3389/fnins.2019.00326. eCollection 2019. PubMed PMID: 31001081; PubMed Central PMCID: PMC6456690.

 

Kutsuma T, Katagiri S, Hayashi T, Yoshitake K, Iejima D, Gekka T, Kohzaki K, Mizobuchi K, Baba Y, Terauchi R, Matsuura T, Ueno S, Iwata T, Nakano T. Novel biallelic loss-of-function KCNV2 variants in cone dystrophy with supernormal rod responses. Doc Ophthalmol. 2019 Mar 15. doi: 10.1007/s10633-019-09679-6. [Epub ahead of print] PubMed PMID: 30877594.

 

Suzuki K, Gocho K, Akeo K, Kikuchi S, Kubota D, Katagiri S, Fujinami K, Tsunoda K, Iwata T, Yamaki K, Igarashi T, Nakano T, Takahashi H, Hayashi T, Kameya S. High-Resolution Retinal Imaging Reveals Preserved Cone Photoreceptor Density and Choroidal Thickness in Female Carriers of Choroideremia. Ophthalmic Surg Lasers Imaging Retina. 2019 Feb 1;50(2):76-85. doi: 10.3928/23258160-20190129-03. PubMed PMID: 30768214.

 

Kondo H, Oku K, Katagiri S, Hayashi T, Nakano T, Iwata A, Kuniyoshi K, Kusaka S, Hiyoshi A, Uchio E, Kondo M, Oishi N, Kameya S, Mizota A, Naoi N, Ueno S, Terasaki H, Morimoto T, Iwaki M, Yoshitake K, Iejima D, Fujinami K, Tsunoda K, Shinoda K, Iwata T. Novel mutations in the RS1 gene in Japanese patients with X-linked congenital retinoschisis. Hum Genome Var. 2019 Jan 8;6:3. doi: 10.1038/s41439-018-0034-6. eCollection 2019. PMID: 30652005

 

Mizobuchi K, Katagiri S, Hayashi T, Yoshitake K, Fujinami K, Kuniyoshi K, Mishima R, Tsunoda K, Iwata T, Nakano T. Clinical findings of end-stage retinitis pigmentosa with a homozygous PDE6A variant (p.R653X). Am J Ophthalmol Case Rep. 2018 Dec 19;13:110-115. doi: 10.1016/j.ajoc.2018.12.019. eCollection 2019 Mar. PubMed PMID: 30619975; PubMed Central PMCID: PMC6307093.

 

Ueno S, Inooka D, Meinert M, Ito Y, Tsunoda K, Fujinami K, Iwata T, Ohde H, Terasaki H. Three cases of acute-onset bilateral photophobia. Jpn J Ophthalmol. 2019 Jan 2. doi: 10.1007/s10384-018-00649-0. [Epub ahead of print] PubMed PMID: 30604114.

 

須賀晶子、吉武和敏、岩田岳、オミックス解析による遺伝性網脈絡膜疾患の病因・病態機序の解明、臨床応用に向けた疾患シークエンス解析、(編集:松本直道、難波栄二、古川洋一)、遺伝子医学 MOOK34、メディカルデュ、2018

 

Gyan Prakash and Takeshi Iwata (Eds), Advances in Vision Research Volume II, Essentials in Ophthalmology, Springer Nature, 2018

 

Katagiri S, Hayashi T, Yoshitake K, Murai N, Matsui Z, Kubo H, Satoh H, Matsufuji S, Takamura T, Yokoo T, Omori Y, Furukawa T, Iwata T, Nakano T. Compound heterozygous splice site variants in the SCLT1 gene highlight an additional candidate locus for Senior-Loken syndrome. Sci Rep. 2018 Nov 13;8(1):16733. doi: 10.1038/s41598-018-35152-6.

 

Nakanishi A, Ueno S, Hayashi T, Katagiri S, Ito Y, Kominami T, Fujinami K, Tsunoda K, Iwata T, Terasaki H. CHANGES OF CONE PHOTORECEPTOR MOSAIC IN AUTOSOMAL RECESSIVE BESTROPHINOPATHY. Retina. 2018 Oct 9. doi:10.1097/IAE.0000000000002363. [Epub ahead of print] PubMed PMID: 30308565.

 

Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK. Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line. Biochem Biophys Res Commun. 2018 Aug 9. pii: S0006-291X(18)31699-1. doi: 10.1016/j.bbrc.2018.08.025. [Epub ahead of print] PubMed PMID: 30100066.

 

Muraoka Y, Iida Y, Ikeda HO, Iwai S, Hata M, Iwata T, Nakayama M, Shimozawa N, Katakai Y, Kakizuka A, Yoshimura N, Tsujikawa A. KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration. Heliyon. 2018 May 14;4(5):e00624. doi: 10.1016/j.heliyon.2018.e00624. eCollection 2018 May. PubMed PMID: 29872758; PubMed Central PMCID: PMC5986307.

 

Inagaki S, Kawase K, Funato M, Seki J, Kawase C, Ohuchi K, Kameyama T, Ando S, Sato A, Morozumi W, Nakamura S, Shimazawa M, Iejima D, Iwata T, Yamamoto T, Kaneko H, Hara H. Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2293-2304.

 

Kawamura Y, Suga A, Fujimaki T, Yoshitake K, Tsunoda K, Murakami A, Iwata T. LRRTM4-C538Y novel gene mutation is associated with hereditary macular degeneration with novel dysfunction of ON-type bipolar cells. J Hum Genet. 2018 May 14. doi: 10.1038/s10038-018-0465-4. [Epub ahead of print] PubMed PMID: 29760528.

 

Xu X, Fang Y, Yokoi T, Shinohara K, Hirakata A, Iwata T, Tsunoda K, Jonas JB, Ohno-Matsui K. POSTERIOR STAPHYLOMAS IN EYES WITH RETINITIS PIGMENTOSA WITHOUT HIGH MYOPIA. Retina. 2018 Apr 26. doi: 10.1097/IAE.0000000000002180. [Epub ahead of print] PubMed PMID: 29708934.

 

Katagiri S, Hosono K, Hayashi T, Kurata K, Mizobuchi K, Matsuura T, Yoshitake K, Iwata T, Nakano T, Hotta Y. Early onset flecked retinal dystrophy associated with new compound heterozygous RPE65 variants. Mol Vis. 2018 Apr 9;24:286-296. eCollection 2018. PubMed PMID: 29681726; PubMed Central PMCID: PMC5893010.

 

Katagiri S, Hayashi T, Mizobuchi K, Yoshitake K, Iwata T, Nakano T. Autosomal dominant retinitis pigmentosa with macular involvement associated with a disease haplotype that included a novel PRPH2 variant (p.Cys250Gly). Ophthalmic Genet. 2018 Jun;39(3):357-365. doi: 10.1080/13816810.2018.1459737. Epub 2018 Apr 9. PubMed PMID: 29630435.

 

Prakashi G, Iwata T. Asian Eye Genetics (AEGC), Guest Editorial, Indian Journal of Ophthalmology 2018

 

Shiga Y, Akiyama M, Nishiguchi KM, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Koichi M, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yamashiro K; Japan Glaucoma Society Omics Group, Kashiwagi K, Iwata T, Mabuchi F, Takamoto M, Ozaki M, Kawase K, Aihara M, Araie M, Yamamoto T, Kiuchi Y, Nakamura M, Ikeda Y, Sonoda KH, Ishibashi T, Nitta K, Iwase A, Shirato S, Oka Y, Satoh M, Sasaki M, Fuse N, Suzuki Y, Cheng CY, Khor CC, Baskaran M, Perera S, Aung T, Vithana EN, Cooke Bailey JN, Kang JH, Pasquale LR, Haines JL; NEIGHBORHOOD consortium, Wiggs JL, Burdon KP, Gharahkhani P, Hewitt AW, Mackey DA, MacGregor S, Craig JE, Allingham RR, Hauser M, Ashaye A, Budenz DL, Akafo S, Williams SEI, Kamatani Y, Nakazawa T, Kubo M. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Hum Mol Genet. 2018 Feb 14. doi: 10.1093/hmg/ddy053. [Epub ahead of print] PubMed PMID: 29452408.

 

Uno Y, Osada N, Sakurai S, Shimozawa N, Iwata T, Ikeo K. Development of genotyping method for functionally relavant variants of cytochromes P450 in cynomogus macaques. Journal of Veterinary Pharmacology and Therapeutics. 2018;41:e30-e34.

 

Khan KN, Kasilian M, Mahroo OAR, Tanna P, Kalitzeos A, Robson AG, Tsunoda K, Iwata T, Moore AT, Fujinami K, Michaelides M. Early Patterns of Macular Degeneration in ABCA4-Associated Retinopathy. Ophthalmology. 2018 Jan 5. pii: S0161-6420(17)32533-2. doi: 10.1016/j.ophtha.2017.11.020. [Epub ahead of print] PubMed PMID: 29310964.

 

Kominami A, Ueno S, Kominami T, Nakanishi A, Ito Y, Fujinami K, Tsunoda K, Hayashi T, Kikuchi S, Kameya S, Iwata T, Terasaki H. Case of cone dystrophy with normal fundus appearance associated with biallelic POC1B variants. Ophthalmic Genet. 2018 Apr;39(2):255-262. doi: 10.1080/13816810.2017.1408846. Epub 2017 Dec 8. PubMed PMID: 29220607.

 

Fiorentino A, Fujinami K, Arno G, Robson AG, Pontikos N, Arasanz Armengol M, Plagnol V, Hayashi T, Iwata T, Parker M, Fowler T, Rendon A, Gardner JC, Henderson RH, Cheetham ME, Webster AR, Michaelides M, Hardcastle AJ; 100,000 Genomes Project, the Japan Eye Genetic Consortium and the UK Inherited Retinal Dystrophy Consortium. Missense variants in the X-linked gene PRPS1 cause retinal degeneration in females. Hum Mutat. 2018 Jan;39(1):80-91. doi: 10.1002/humu.23349. Epub 2017 Oct 17. PubMed PMID: 28967191.

 

Shiga Y, Nishiguchi KM, Kawai Y, Kojima K, Sato K, Fujita K, Takahashi M, Omodaka K, Araie M, Kashiwagi K, Aihara M, Iwata T, Mabuchi F, Takamoto M, Ozaki M, Kawase K, Fuse N, Yamamoto M, Yasuda J, Nagasaki M, Nakazawa T; Japan Glaucoma Society Omics Group (JGS-OG). Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7. PLoS One. 2017 Dec 20;12(12):e0186678. doi: 10.1371/journal.pone.0186678. eCollection 2017. PubMed PMID: 29261660.

 

Kato Y, Hanazono G, Fujinami K, Hatase T, Kawamura Y, Iwata T, Miyake Y, Tsunoda K. Parafoveal Photoreceptor Abnormalities in Asymptomatic Patients With RP1L1 Mutations in Families With Occult Macular Dystrophy. Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6020-6029. doi: 10.1167/iovs.17-21969.

 

Shinozaki Y, Kashiwagi K, Namekata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T, Koizumi S. Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy. JCI Insight. 2017 Oct 5;2(19). pii: 93456.

 

Mabuchi F, Mabuchi N, Takamoto M, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Aihara M, Iwata T, Araie M. Japan Glaucoma Society Omics Group (JGS-OG). Genetic Variant Near PLXDC2 Influences the Risk of Primary Open-angle Glaucoma by Increasing Intraocular Pressure in the Japanese Population. J Glaucoma. 2017 Sep 19.

 

Yamashiro K, Mori K, Honda S, Kano M, Yanagi Y, Obana A, Sakurada Y, Sato T, Nagai Y, Hikichi T, Kataoka Y, Hara C, Koyama Y, Koizumi H, Yoshikawa M, Miyake M, Nakata I, Tsuchihashi T, Horie-Inoue K, Matsumiya W, Ogasawara M, Obata R, Yoneyama S, Matsumoto H, Ohnaka M, Kitamei H, Sayanagi K, Ooto S, Tamura H, Oishi A, Kabasawa S, Ueyama K, Miki A, Kondo N, Bessho H, Saito M, Takahashi H, Tan X, Azuma K, Kikushima W, Mukai R, Ohira A, Gomi F, Miyata K, Takahashi K, Kishi S, Iijima H, Sekiryu T, Iida T, Awata T, Inoue S, Yamada R, Matsuda F, Tsujikawa A, Negi A, Yoneya S, Iwata T, Yoshimura N. A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration. Sci Rep. 2017;7:9196.

 

Mabuchi F, Mabuchi N, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Takamoto M, Aihara M, Iwata T, Kawase K, Shiga Y, Nishiguchi KM, Nakazawa T, Ozaki M, Araie M; Japan Glaucoma Society Omics Group (JGS-OG). Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma. PLoS One. 2017;12(8):e0183709.

 

Hayashi T, Sasano H, Katagiri S, Tsunoda K, Kameya S, Nakazawa M, Iwata T, Tsuneoka H. Heterozygous deletion of the OPA1 gene in patients with dominant optic atrophy. Jpn J Ophthalmol. 2017 Jul 1. doi: 10.1007/s10384-017-0522-0.

 

Ueno S, Nakanishi A, Sayo A, Kominami T, Ito Y, Hayashi T, Tsunoda K, Iwata T, Terasaki H. Differences in ocular findings in two siblings: one with complete and other with incomplete achromatopsia. Doc Ophthalmol. 2017 Apr;134(2):141-147.

 

Shim MS, Takihara Y, Kim K-Y, Iwata T, Yue BYJT, Inatani M, Weinreb RN, Perkins GA, and Ju W-K. Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2017 Jan 19;7:40460.

 

Takeshi Iwata. Japan Eye Genetics Consortium (JEGC) for Hereditary Retinal Diseases, Advances in Vision Research Volume I, Essentials in Ophthalmology, Springer, 2017;1:9-20.

 

Gyan Prakash, Takeshi Iwata. Foundation of Asian Eye Genetics Consortium (AEGC), Advances in Vision Research Volume I, Essentials in Ophthalmology, Springer, 2017;1:1-8.

 

Akiyama G, Matsumoto CS, Shinoda K, Terauchi G, Matsumoto H, Watanabe E, Iwata T, Mizota A, Miyake Y. Intraoperative electrophysiological evaluations of macular function during peripheral scleral indentation. Sci Rep. 2016 Oct 20;6:35164.

 

Ueno S, Nakanishi A, Kominami T, Ito Y, Hayashi T, Yoshitake K, Kawamura Y, Tsunoda K, Iwata T, Terasaki H. In vivo imaging of a cone mosaic in a patient with achromatopsia associated with a GNAT2 variant. Jpn J Ophthalmol. 2016 Oct 7.

 

Minegishi Y, Nakayama M, Iejima D, Iwata T. Significance of Optineurin Mutations in Glaucoma and Other Diseases. Prog Ret Eye Res 2016;S1350-9462(16)30061-1.

 

Minegishi Y, Sheng X, Yoshitake K, Sergeev Y, Iejima D, Shibagaki Y, Monma N, Ikeo K, Furuno M, Zhuang W, Liu Y, Rong W, Hattori A, Iwata T. CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability. Sci Rep 2016;6:33742.

 

Iwata T. Establishment of the Indian Chapter for Asian Eye Genetics Consortium. Indian J Ophthalmol. 2016;64:484

 

Fujinami K, Kameya S, Kikuchi S, Ueno S, Kondo M, Hayashi T, Shinoda K, Machida S, Kuniyoshi K, Kawamura Y, Akahori M, Yoshitake K, Katagiri S, Nakanishi A, Sakuramoto H, Ozawa Y, Tsubota K, Yamaki K, Mizota A, Terasaki H, Miyake Y, Iwata T, Tsunoda K. Novel RP1L1 Variants and Genotype-Photoreceptor Microstructural Phenotype Associations in Cohort of Japanese Patients With Occult Macular Dystrophy. Invest Ophthalmol Vis Sci. 2016;57:4837-46

 

Suga A, Mizota A, Kato M, Kuniyoshi K, Yoshitake K, Sultan W, Yamazaki M, Shimomura Y, Ikeo K, Tsunoda K, Iwata T. Identification of novel mutations in the LRR-cap domain of C21orf2 in Japanese patients with retinitis pigmentosa and cone-rod dystrophy. Invest Ophthalmol Vis Sci 2016;57:4255-4263

 

Kuniyoshi K, Hayashi T, Sakuramoto H, Mishima H, Tsuneoka H, Tsunoda K, Iwata T, Shimomura Y. New truncation mutation of the NR2E3 gene in a Japanese patient with enhanced S-cone syndrome. Jpn J Ophthalmol. 2016 Aug 13.

 

Yagura K, Shinoda K, Matsumoto S, Terauchi G, Kawashima M, Watanabe E, Matsumoto H, Iwata T, Mizota A, Miyake Y. Electroretinographic evaluations of retinal function before, just after, and after intravitreal injections. Sci Rep 2016 Aug 5;6:31104. doi: 10.1038/srep31104.

 

Nakanishi A, Ueno S, Hayashi T, Katagiri S, Kominami T, Ito Y, Gekka T, Masuda Y, Tsuneoka H, Shinoda K, Hirakata A, Inoue M, Fujinami K, Tsunoda K, Iwata T, Terasaki H. Clinical and genetic findings of autosomal recessive bestrophinopathy in Japanese cohort. Am J Ophthalmol. 2016;S0002-9394:30198-2

 

Biswas P, Chavali VR, Agnello G, Stone E, Chakarova C, Duncan JL, Kannabiran C, Homsher M, Bhattacharya SS, Naeem MA, Kimchi A, Sharon D, Iwata T, Riazuddin S, Reddy GB, Hejtmancik JF, Gerogiou G, Riazuddin SA, Ayyagari R. A missense mutation in the ASRGL1 gene is involved in causing autosomal recessive retinal degeneration. Hum Mol Genet. 2016

 

Kuniyoshi K, Muraki-Oda S, Ueyama H, Toyoda F, Sakuramoto H, Ogita H, Irifune M, Yamamoto S, Nakao A, Tsunoda K, Iwata T, Ohji M, Shimomura Y. Novel mutations in the gene for α-subunit of retinal cone cyclic nucleotide-gated channels in a Japanese patient with congenital achromatopsia. Jpn J Ophthalmol. 2016;60:187-97

 

Katagiri S, Hayashi T, Yoshitake K, Akahori M, Ikeo K, Gekka T, Tsuneoka H, Iwata T. RPE65 mutations in two Japanese families with Leber congenital amaurosis. Ophthalmic Genetics 2016;37:161-169

 

Nakanishi A, Ueno S, Kawano K, Ito Y, Kominami T, Yasuda S, Kondo M, Tsunoda K, Iwata T, Terasaki H. Pathologic Changes of Cone Photoreceptors in Eyes With Occult Macular Dystrophy. Invest Ophthalmol Vis Sci. 2015;56:7243-9

 

Iejima D, Nakayama M, Iwata T, HTRA1 Overexpression Induces the Exudative Form of Age-Related Macular Degeneration. Age-Related Macular Degeneration. J Stem Cells 2015;10:193-203

 

Katagiri S, Hayashi T, Ohkuma Y, Sekiryu T, Takeuchi T, Gekka T, Kondo M, Iwata T, Tsuneoka H. Mutation analysis of BEST1 in Japanese patients with Best's vitelliform macular dystrophy. Br J Ophthalmol. 2015;99:1577-82

 

Katagiri S, Hayashi T, Yoshitake K, Sergeev Y, Akahori M, Furuno M, Nishino J, Ikeo K, Tsunoda K, Tsuneoka H, Iwata T. Congenital Achromatopsia and Macular Atrophy Caused by a Novel Recessive PDE6C Mutation (p.E591K). Ophthalmic Genet. 2015;36:137-44

 

Kato Y, Tsunoda K, Fujinami K, Iwata T, Saga M, Oguchi Y. Association of Retinal Artery and Other Inner Retinal Structures With Distribution of Tapetal-like Reflex in Oguchi's Disease. Invest Ophthalmol Vis Sci. 2015;56:2162-72

 

Iwata T. Author Response: Postnatal Overexpression of the Human ARMS2 Gene Does Not Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models. Invest Ophthalmol Vis Sci. 2015; 56:1389

 

Kuniyoshi K, Sakuramoto H, Yoshitake K, Ikeo K, Furuno M, Tsunoda K, Kusaka S, Shimomura Y, Iwata T. Reduced rod electroretinograms in carrier parents of two Japanese siblings with autosomal recessive retinitis pigmentosa associated with PDE6B gene mutations. Doc Ophthalmol. 2015;131:71-9

 

Iejima D, Itabashi T, Kawamura Y, Noda T, Yuasa S, Fukuda K, Oka C, Iwata T. High-Temperature Requirement A Serine Peptidase 1 Gene is Transcriptionally Regulated by Insertion/Deletion Nucleotides Located at the 3 Prime End of Age-Related Maculopathy Susceptibility 2 Gene in Patients with Age-Related Macular Degeneration. The Journal of Biological Chemistry 2015;290:2784-97

 

Kuniyoshi K, Ikeo K, Sakuramoto H, Furuno M, Yoshitake K, Hatsukawa Y, Nakao A, Kusaka S, Shimomura Y, Iwata T. Novel nonsense and splice site mutations in CRB1 gene in two Japanese patients with early-onset retinal dystrophy Documenta Ophthalmologica. Documenta Ophthalmologica 2015;130:49-55

 

Katagiri S, Hayashi T, Akahori M, Itabashi T, Nishino J, Yoshitake K, Furuno M, Ikeo K, Okada T, Tsuneoka H and Iwata T. RHO mutations (p.W126L and p.A346P) in two Japanese families with autosomal dominant retinitis pigmentosa. Journal of Ophthalmology 2014;2014:210947. doi: 10.1155/2014/210947

 

Gallenberger M, Kroeber M, Koch M, März L, Fuchshofer R, Iwata T, Braunger BM, Tamm ER. Heterozygote Wdr36-deficient mice do not develop glaucoma. Experimental Eye Research 2014;128:83-91

 

Nakayama M, Iejima D, Akahori M, Kamei J, Goto A, Iwata T. Overexpression of Htra1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice. Investigative Ophthalmology and Visual Science 2014;55:6514-6523

 

Katagiri S, Akahori M, Sergeev Y, Yoshitake K, Ikeo K, Furuno M, Hayashi T, Kondo M, Ueno S, Tsunoda K, Shinoda K, Kuniyoshi K, Tsurusaki Y, Matsumoto N, Tsuneoka H, Iwata T. Whole exome analysis identifies frequent CNGA1mutations in Japanese population with autosomal recessive retinitis pigmentosa. PLoS One 2014;9(9):e108721

 

Katagiri S, Hayashi T, Yoshitake K, Akahori M, Ikeo K, Gekka T, Tsuneoka H, Iwata T. Novel C8orf37 mutations in patients with early-onset retinal dystrophy, macular atrophy, cataracts, and high myopia. Ophthalmic Genetics 2014;12:1-8

 

Tanito M, Hara K, Akahori M, Harata A, Itabashi T, Takai Y, Kaidzu S, Ohira A, Iwata T. Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits. Acta Ophthalmologica 2014; Aug 12

 

Matsumoto CS, Shinoda K, Matsumoto H, Funada H, Sasaki K, Minoda H, Iwata T, Mizota A. Pattern visually evoked potentials elicited by organic electro-luminescence screen. BioMed Research International 2014:606951

 

Matsumoto CS, Nakagomi R, Matsumoto H, Minoda H, Shinoda K, Iwata T, Mizota A. Binocular interaction of visually evoked cortical potentials elicited by dichoptic binocular stimulation Journal of Vision 2014;14(11). pii4

 

Matsumoto CS, Shinoda K, Matsumoto H, Seki K, Nagasaka E, Iwata T, Mizota A. What monitor can replace cathode ray tube for visual stimulation to elicit multifocal electroretinograms? Journal of Vision 2014;14(9) pii:2

 

Kobayashi H, Okamoto H, Murakami A, Iwata T. Plasma Proteome Analysis On Cynomolgus Monkey (Macaca fascicularis) Pedigrees With Early Onset Drusen Formation. Journal of Experimental Animals 2014;63:305-310

 

Kuniyoshi K, Sakuramoto H, Yoshitake K, Abe K, Ikeo K, Furuno M, Tsunoda K, Kusaka S, Shimomura Y, Iwata T. Longitudinal clinical course of three Japanese patients with Leber congenital amaurosis/severe early childhood onset retinal dystrophy with RDH12 mutation. Documenta Ophthalmologica 2014;128:219-228

 

Katagiri S, Akahori M, Hayashi T, Yoshitake K, Gekka T, Ideo K, Tsuneoka H, Iwata T. Autosomal recessive cone-rod dystrophy associated with compound heterozygous mutations in the EYS gene. Documenta Ophthalmologica 2014;128:211-2117

 

Ohkuma Y, Hayashi T, Sakai T, Watanabe A, Yamada H, Akahori M, Itabashi T, Iwata T, Noda T, Tsuneoka H.: Retinal angiomatous proliferation associated with risk alleles of ARMS2/HTRA1 gene polymorphisms in Japanese patients. Journal of Clinical Ophthalmology 2014;8:143-8

 

Iwata T, Animal Models for Eye Diseases, Handbook of Laboratory Animal Science III, (Editor: Hau J and Schapiro SJ) CRC Press 2014;195-217

 

赤堀正和、岩田岳、黄斑ジストロフィー、特集 ゲノムと網膜関連疾患の関与を探る(編集:山城健児)、RETINA Medicine、先端医学社 2014;3:33-37

 

Katagiri S, Yoshitake K, Akahori M, Hayashi T, Furuno M, Nishino J, Ikeo K, Tsuneoka H, Iwata T. Whole-exome sequencing identifies a novel ALMS1 mutation (p.Q2051X) in two Japanese brothers with Alstrom Syndrome. Molecular Vision 2013;19:2393-406

 

Sakuramoto H, Kuniyoshi K, Tsunoda K, Akahori M, Iwata T, Shimomura Y. Two siblings with late-onset cone-rod dystrophy and no visible macular degeneration. Journal of Clinical Ophthalmology. 2013;7:1703-11

 

Nakamura N, Tsunoda K, Fujinami K, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Iwata T, Miyake Y. [Long-term observation over ten years of four cases of cone dystrophy with supernormal rod electroretinogram]. Nihon Ganka Gakkai Zasshi. 2013;117:629-40

 

Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y. Molecular characteristics of four Japanese cases with KCNV2 retinopathy: report of novel disease-causing variants. Molecular Vision 2013;19:1580-90

 

Minegishi Y, Iejima D, Kobayashi H, Chi Z-L, Kawase K, Yamamoto T, Seki T, Yuasa S, Fukuda K, Iwata T. Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma. Human Molecular Genetics 2013;22:3559-67

 

岩田岳、日米の眼研究の架け橋 Jin H. Kinoshita先生を偲んで (編集:堀田喜裕)、あたらしい眼科、メディカル葵出版 2013;30:1417-8

 

岩田岳、古野正朗、池尾一穂、全エクソーム解析による遺伝性網脈絡膜疾患の原因遺伝子探索、エクソーム解析 ‐成果と将来‐ (編集:松本直道)、医学のあゆみ、医歯薬出版株式会社 2013;245:401-407

 

岩田岳、眼疾患をきたす遺伝子変化、第117回日眼評議員会指名講演:「眼疾患と遺伝子」をより理解するために、日本の眼科、公益社団法人日本眼科医会 2013;84:265-269

 

岩田岳、Optineurinと正常眼圧緑内障、Digestシリーズ (編集:本庶佑)、Medical Science Digest、ニューサイエンス社 2013;39:2-4

 

岩田岳、緑内障の遺伝子とその機能解析、緑内障の病態と疫学、高齢者の視覚障害とそのケア(編集:小口芳久)、公益財団法人長寿科学振興財団、2013;107-118

 

Chen CJ, Scholl HP, Birch DG, Iwata T. Miller NR, Goldberg MF. Characterizing the phenotype and genotype of a family with occult macular dystrophy. JAMA Ophthalmology 2012;130:1554-9

 

Thakkinstian A, McEvoy M, McKay GJ, Chakravarthy U, Chakrabati S, Kaur I, Silvetri G, Francis P, Iwata T, Akahori M, Farwick A, Euijung R, Edward A, Seddon JM, Attia J. The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis. American Journal of Epedemiology 2012;176:361-372

 

Kabuto T, Takahashi H, Goto-Fukuura Y, Igarashi T, Akahori M, Kameya S, Iwata T, Mizota A, Yamaki K, Miyake Y, Takahashi H. A new mutation in the RP1L1 gene in a patient with occult macular dystrophy associated with a depolarizing pattern of focal macular electroretinograms. Molecular Vision 2012;18:1031-9

 

Tsunoda K, Usui T, Hatase T, Yamai S, Fujinami K, Hanazono G, Shinoda K, Ohde H, Akahori M, Iwata T, Miyake Y. Clinical characteristics of occult macular dystrophy in a large family with mutation of RP1L1 gene. Retina 2012;32:1135-47

 

Hara K, Akahori M, Tanito M, Kaidzu S, Ohira A, Iwata T. Analysis of LOXL1 gene variants in Japanese patients with branch retinal vein occlusion. Molecular Vision 2011;17:3309-13

 

Fujinami K, Akahori M, Fukui M, Tsunoda K, Iwata T, Miyake Y. Stargardt disease with preserved central vision: identification of a putative novel mutation in ATP-binding cassette transporter gene. Acta Ophthalmologica 2011;89(3):e297-8. doi: 10.1111/j.1755-3768.2009.01848.x

 

Jin ZB, Okamoto S, Osakada F, Homma K, Assawachananont J, Hirami Y, Iwata T, Takahashi M. Modeling retinal degeneration using patient-specific induced pluripotent stem cells. PLoS One 2011;6(2):e17084

 

岩田岳、眼科と補体、補体への招待、メディカルビュー社 2011;189-193

 

岩田岳、視力・色覚を司る黄斑の生理機能と黄斑変性の分子メカニズム、視覚・聴覚のNeuroscience、実験医学、羊土社 2011;29:526-532

 

Shen X, Ying H, Qiu Y, Park J-S, Shyam R, Chi Z-L, Iwata T, Yue BYJT. Processing of optineurin in neuronal cells. The Journal of Biological Chemistry 2011;286:3618-29

 

Akahori M, Tsunoda K, Miyake Y, Fukuda Y, Ishiura H, Tsuji S, Hatase T, Nakamua M, Ohde H, Itabashi T, Okamoto H, Takada Y, and Iwata T. Dominant mutations in RP1L1 gene are responsible for occult macular dystrophy. The American Journal of Human Genetics 2010;87:424-429

 

Chi Z-L, Yoshida T, Lambris JD, and Iwata T. Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on Cynomolgus monkey with early-onset macular degeneration. Currrent Topics on Complement and Eye Disease, Advances in Experimental Medicine and Biology 2010;703:127-135

 

Chi Z-L, Yasumoto F, Sergeev Y, Minami M, Obazawa M, Kimura I, Takada Y, and Iwata T. Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice. Human Molecular Genetics 2010;19:3806-3815

 

Chi Z-L, Akahori, A, Obazawa M, Minami M, Noda T, Nakaya N, Tomarev S, Kawase K, Yamamoto T, Noda S, Sasaoka M, Shimazaki A, Takada Y, and Iwata T. Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Human Molecular Genetics 2010;19:2605-2615

 

Okamoto H, Umeda S, Nozawa T, Suzuki MT, Yoshikawa Y, Matsuura ET, and Iwata T. Comparative proteomic analyses of macular versus peripheral retina in Cynomogus monkeys (Macaca fascicularis). Experimental Animal 2010;59:171-178

 

Fujikawa K, Iwata T, Inoue K, Akahori M, Kadotani H, Fukaya M, Watanabe M, Chang Q, Barnett EM, and Swat W. Vav2 and Vav3 as candidate disease gene for spontaneous glaucoma in mice and human. PLoS One 2010;5:e9050

 

Goto A, Akahori A, Okamoto H, Minami M, Terauchi N, Haruhata Y, Obazawa M, Noda T, Honda M, Mizota A, Tanaka M, Hayashi T, Tanito M, Ogata N, and Iwata T. Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population. Journal of Ocular Biology, Disease, and Informatics 2009;2:164-175

 

岩田岳、緑内障遺伝子改変動物の基礎、眼薬理 2009;23:67-70

 

岩田岳、眼疾患バイオマーカーの探索、医療 2008;62:512-515

 

Tanito M, Minami M, Akahori M, Kaidzu S, Takai Y, Ohira A, and Iwata T. LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. Molecular Vision 2008;14:1898-1905

 

Kaidzu S, Tanito M, Ohira A, Umeda S, Suzuki M, Yoshikawa Y, and Iwata T. Immunohistochemical analysis of aldehyde-modified proteins in drusen in cynomolgus monkeys (Macaca fascicularis). Experimental Eye Research 2008;86:856-859

 

岩田岳、緑内障の動物モデル(2)−マウスモデル、その他−、あたらしい眼科、株式会社メディカル葵出版 2007;24:1049

 

岩田岳、緑内障の動物モデル(1)−霊長類モデル、ラットモデル−、あたらしい眼科、株式会社メディカル葵出版 2007;24:909

 

Iwata T. Complement Activation of Drusen in Primate Model (Macaca fascicularis) for Age-Related Macular Degeneration. Currrent Topics in Innate Immunity, Advances in Experimental Medicine and Biology, Springer 2007;251-259

 

Iwata T. and Tomarev S. Animal Models for Eye Diseases and Therapeutics, Source Book of Biomedical Research, Humana Press Inc. 2007;279-287

 

岩田岳、網膜・硝子体のプロテオーム解析、日本の眼科、公益社団法人日本眼科医会 2007;78:577-582

 

Yoshida T, Wan AD, Zhang H, Sakamoto R, Okamoto H, Minami M, Obazawa M, Mizota A, Tanaka M, Saito Y, Takagi I, Hoh J, and Iwata T. HTRA1 Promoter Polymorphism Predisposes Japanese to AMD. Molecular Vision 2007;13:545-548

 

Shibuya M, Okamoto H, Nozawa T, Utsumi J, Reddy VN, Echizen H, Tanaka Y, and Iwata T. Proteomic & Transcriptomic Analyses of Retinal Pigment Epithelial Cells Exposed to REF-1/TFPI-2, a Growth Promoting Factor. Investigative Ophthalmology and Visual Science 2007;48:516-521

 

岩田岳、我が国の先端的眼科研究の立場から −失明を防ぐための多面的なアプローチ−、バイオサイエンスとインダストリー 2006;64:625-629

 

岩田岳、加齢黄斑変性の遺伝子研究の最前線、特集:網膜脈絡膜変性疾患のアップデート、あたらしい眼科、株式会社メディカル葵出版 2006;23:1125-1131

 

Darmanin C, Iwata T, Carper DA and El-Kabbani O. Discovery of potential sorbitol dehydrogenase inhibitors from virtual screening. Journal of Medical Chemistry 2006;59:558-560

 

Okamoto H, Umeda S, Obazawa M, Minami M, Noda T, Mizota A, Honda M, Tanaka M, Koyama R, Takagi I, Sakamoto Y, Saito Y, Miyake Y, and Iwata T. Complement Factor H Polymorphisms in Japanese Population with Age-Related Macular Degeneration. Molecular Vision 2006;12:156-158

 

Hejtmancik JF, Kantorow M, and Iwata T. Models of Age Related Vision Problems, Handbook of Models for Human Aging. Academic Press, Elsevier Inc. 2006;812-828

 

Izumi K, Kurosaka D, Iwata T, Oguchi Y, Tanaka Y, Mashima Y, and Tsubota K. Involvement of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Corneal Fibroblasts during Corneal Wound Healing. Investive Ophthalmology and Visual Science 2006;47:591-598

 

岩田岳、遺伝子解析の現状、またその行方は? 打倒!加齢黄斑変性、眼科インストラクションコース株式会社メディカルビュ - 2005;20-23

 

Umeda S, Suzuki MT , Okamoto H, Ono F, Mizota A, Terao K, Yoshikawa Y, Tanaka Y, and Iwata T. Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis). FASEB Journal 2005;19:1683-1685

 

Umeda S, Ayyagari R, Allikmets R, Suzuki MT, Karoukis AJ, Ambasudhan R, Zernant J, Okamoto H, Ono F, Terao K, Atsushi M, Yoshikawa Y, Tanaka Y, and Iwata T. Early onset macular degeneration with drusen in a cynomolgus monkey (Macaca fascicularis) pedigree caused by a novel gene mutation. Investive Ophthalmology and Visual Science 2005;46:683-691

 

岩田岳、真島行彦、インベーダー法を用いた緑内障の遺伝子解析」 Bio Medical Quick Review Net  記事番号 4001 http://www.medicaldo.co.jp/application_r.html 株式会社メディカルデゥ 2004

 

Funayama T, Ishikawa K, Ohtake Y, Tanino T, Kurosaka D, Kimura I, Sohma K, Suzuki K, Ideta H, Nakamoto K, Yasuda N, Fujimaki T, Murakami A, Asaoka R, Hotta Y, Kimura A, Tanihara H, Kanemoto T, Mishima H, Fukuchi T, Abe H, Iwata T, Oguchi Y, Kudoh J, Shimizu N, and Mashima Y. Variants in Optineurin Gene and their Association with Tumor Necrosis Factor-alpha (-857C>T) Polymorphisms in Japanese Patients with Glaucoma. Investigative Ophthalmology and Visual Science 2004;45:4359-4367

 

Ishikawa K, Funayama T, Ohtake Y, Tanino T, Kurosaka D, Suzuki K, Ideta H, Fujimaki T, Tanihara H, Asaoka R, Naoi N, Yasuda N, Iwata T, and Mashima Y. Novel MYOC Gene Mutation, Phe369Leu, in Japanese Patients with Primary Open-Angle Glaucoma Detected by Denaturing High-Performance Liquid Chromatography. Journal of Glaucoma 2004;13:466-471

 

Niizeki H, Matsunaga T, Iwata T, Shimizu T, Kurimoto I, Naruse T, Inoko H, Streilein J W. The MICA5.1 allele is not associated with susceptibility to effects of ultraviolet-B radiation on induction of contact hypersensitivity. Journal of Dermatology Science 2004;35:221-223

 

Obazawa M, Mashima Y, Sanuki N, Noda S, Kudoh J, Shimizu N, Tanaka Y, and Iwata T. Comparable Analysis of Porcine Optineurin and Myocilin Expression in Trabecular Meshwork Cells and Astrocytes from Optic Nerve Head. Investigative Ophthalmology and Visual Science 2004;45:2652-2659

 

Tanaka Y, Utsumi J, Matsui M, Sudo T, Nakamura N, Mutoh M, Kajita A, Sone S, Kigasawa K, Shibuya M, Reddy VN, Zhang Q, and Iwata T. Purification, Molecular Cloning, and Expression of a Novel Growth Promotive Factor for Retinal Pigment Epithelial Cells, REF-1/TFPI-2. Investigative Ophthalmology Visual Science 2004;45:245-252

 

岩田岳、渋谷昌彦、REF−1の機能解析: Applied Biosystems 1700 ケミルミネッセントマイクロアレイアナライザを用いた網膜色素上皮細胞増殖因子 REF-1 の機能解析 バイオビート http://www.appliedbiosystems.co.jp/website/jp/biobeat/top.jsp 日本アプライドバイオシステムズ株式会社 2004

 

Izumi K, Mashima Y, Obazawa M, Ohtake Y, Tanino T, Miyata H, Tanaka Y, and Iwata T. Variants of Myocilin Gene in Japanese Patients With Normal Tension Glaucoma. Ophthalmic Research 2003;35:345-350

 

Zhang Q, Mashima Y, Noda S, Imamura Y, Kudoh J, Shimizu N, Nishiyama T, Umeda S, Tanaka Y, and Iwata T. Characterization of AOC2 Gene Encoding a Copper-binding Amine Oxidase Expressed Specifically in Retina. Gene 2003;318:45-53

 

Umeda S, Suzuki MT, Yoshikawa Y, Iwata F, Fujiki K, Kanai A, Sanuki N, Tanaka Y, and Iwata T. Cloning and Characterization of ELVLO4 Gene in Cynomolgus (Macaca fascicularis) Monkey. Experimental Animal 2003;52:(2)

 

Darmanin C, Iwata T, Carper DA, Sparrow LG, Chung R P-T and El-Kabbani O. Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase. Acta Crystallographica 2003;D59:558-560